Category Archives: Health Care

Beware the Bandersnatch my son (aka the “link”)

If I read the word “link” one more time in some ostensibly serious health article I will – well, let’s just say that like Dorothy Parker’s Tonstant Weader I will thwow up.

Looks like a Bandersnatch to me …

Last week “scientists” apparently linked one’s gait as one aged to one’s likelihood of developing Alzheimer’s. Yet another observational study, casting about for some connection to something; naturally they eventually found some tenuous connection somewhere – at least one that they could write a press release about.

(As a researcher once described estrogen – “a drug in search of a disease”.)

No mention of whether this gait thing might have had something to do with other, perhaps undiagnosed, problems such as osteoarthritis or inner ear issues or what-have-you. No, one more thing for us to worry about as we get older – our damn gait.

Earlier headlines with that vile word “link” (plus variations like “linked”, “linking” and so on) always seem to be in the headline, which, of course, is what most people read. So we read that higher levels of Vitamin D3 are linked to all manner of marvelous things, from not getting cancer and heart disease to staying young and sharp and simply mah-velous. Never mind that when you simply test people who are well and compare them to people who are not, measure their “level” of D3 (as though all of us have the same ideal level) and then say, ‘oh, look, high D means better health so why don’t we all take a supplement” you have no way of knowing which came first, the good health or the D3. For all we know, various diseases deplete the body of D3 and the lack of the vitamin is not the cause of the problem but its consequence.

A number of more cautious researchers have been saying exactly this, to no avail. Various and sundry institutions from the Cancer Agency to the WHO have all decided to chime in with their recommendations that people take supplements.

This same kind of nonsense proliferated in the talk around estrogen for pretty much most of the 20th century.  Researchers gushed that women who took estrogen “replacement” therapy (later “hormone replacement therapy” or HRT after it was found that estrogen alone could cause endometrial cancer) kept women young and healthy and prevented heart disease and dementia and probably hives and hangnails.

Replacement is in quotes earlier, incidentally, because it makes no sense to consider the hormone level of a woman of 23 normal for a woman at all other stages of life, particularly midlife, when all women’s hormones naturally decline.

Observational study upon observational study found a correlation (“link”)  between women who took hormones and improved cardiac function, fewer heart attacks and strokes, better health, you-name-it.  Well, except for the smidgeon of extra risk relating to breast cancer which epidemiologists dismissed as irrelevant. Of course this was not irrelevant to women, who didn’t rush to take hormones in droves, much to the researchers’ dismay.

Then the other show dropped. The largest clinical trial in history, the Women’s Health Initiative definitely showed that not only did estrogen not protect women from various and sundry age-related conditions, it actually could cause them.  Cardiac disease was higher in women who took hormones and there was nothing “healthy” about HRT at all.

But hey, they had studies that “linked” estrogen use with health and who were we to argue?

A lot of people ask me about supplements, Calcium and D3, this and that, largely, I think, because of those headlines linking this and that arcane nutrient with health. Which is where my problem with all of this lies.

You can print whatever nonsense you want, provided you don’t make it sound as though you know what you’re talking about. Especially in the headline. People actually change their behavior based on these things. People start taking things, adding things, subtracting things. Forgetting that health is multifactorial, complex and begins in the womb.

You won’t have strong bones as an adult if you were malnourished as a child. Wealth tends to lead to health. People are different. And the nutrients we ingest in food are in a balance and ratio that the body can absorb. Versus our best-guess estimate of what an ideal amount of D3 or B3 or T3* might be.

So beware the dreaded link as though it were the bandersnatch. On average, I think the latter is more benign.

 

*Tylenol 3

On Clutter, Hoarding and Medical Mistakes

Nobody likes a crisp, neat look more than I do – Ikea wouldn’t be the multi-gazillion corporation it is without my patronage throughout the years. I own pretty much every KASSETT and GLOK organizer doo-dad they make. (I like that they sound Klingon.) Given the sheer number of articles, blogs, television shows and companies on clutter (and its crazy cousin in the attic, hoarding) I am clearly not the only person with this particular fascination.

I sometimes think that if I could just create a prefect, clutter-free world then, as Buckminster Fuller suggested, everything I wrote and worked on would be effortlessly beautiful. Of course I sometimes also think of  Roswell and of the aliens that live among us. So it’s not like I’m totally sane all the time.

Trouble is, compared to a lot of people I’m bloody Einstein, given that this mania for de-cluttering the detritus of life appears to have permeated and penetrated into large areas of life; areas that simply do not lend themselves to neat solutions.

Some things are inherently messy and there’s not a damn thing we can do about it.

Take disease/illness and the complexity of patient care, all of which I have gone on about ad nauseum.  Much as we would like to make it all iPad-neat and high-tech cool the reality of surgery and hospitals and elder care and whatnot just isn’t going to be minimalist-zen. And trust me, if you’re a patient you don’t want it to be because if your clinical team decides you’re just a carbon copy of everybody else you’re going to get shoddy care.

Right on cue enter a medical director at the  Birmingham University Hospital in Britain who, enchanted with the local BMW plant’s “flawless”, failure-free operation, wondered how the hospital could duplicate the plant’s figurative tracking down of every “loose screw”.  (Yes, I am biting my tongue.) One assumes the director hoped patients would leave the hospital all shiny with that new car smell …

So, mixing everything from metaphors to minds, a “bespoke computer system” was ordered – no doubt to bring German engineering to an off-the-rack hospital. The cost? Some 4 million pounds sterling or approximately $5.4 million U.S..This computer’s claim to fame was that its operation actually mimicked the dashboard of a car, presumably that of the aforementioned BMW. The dashboard thingies became standard issue at the hospital; their point to “catch” problems before or as they evolved, problems ranging frompost-surgical infection levels and falls to bed sores. Which sounds sensible you might think. Except you’d be wrong.

A computer that posh couldn’t possibly stop at patient problems; where’s the fun in that? So those bedside dashboards also have dials to let managers and ward sisters know when efficiency (“benchmarked against comparable wards and recent performance”) falls, even as response time is recorded to let higher-ups know who and what might be doing poorly. Ouch. So not only is Big Brother watching but his name is HAL.

The mind boggles. German engineered hospital care run with military precision – oops, that has nasty militaristic WWII overtones. Rephrase, rephrase …

(For more see The Economist, 16 June 2012.  http://www.economist.com/node/21556924)

Admittedly it is tempting and attractive, to believe that better health, better post surgical and treatment outcomes, fewer medical errors as simply being a matter of organization and method. Problem is, Sherlock, people go into hospital for a reason – and that reason is that they’re sick, injured or otherwise poorly. These days, given cost containment issues, hospitalized patients tend to be really sick. Often they are also old, which means they are frail and have a lot of other things wrong with them: from cardiac issues to arthritis and various and sundry ailments.

True, we do much better with acute care than we did even 40 years ago – brain tumours that would have killed your grandfather can sometimes be removed, e.g., – but the reality of patient care is that some people do get worse and some people die. Even the ones who do all right and go home are rarely if ever  good as new. Surgeries cause scar tissue and pain and a host of other problems. As they used to say, the only really safe surgery is the one they do on the other guy.  No nifty BMW dashboard can change that.

A few more staff nurses might but that’s another story.

So, boys and girls, can anyone tell me what some issues with this perspective might be? Anyone? Anyone except Tiffany? Sigh. OK. Tiffany. That’s right.Human bodies, physiology, biology: these are complex, messy, hard to classify and all too often problems that arise are  idiosyncratic and incomprehensible. Funny that, but bodies don’t tend to have read the textbooks. Many people do well but some do not and each case is different.

True, the medical system does screw up (as America’s Institute of Medicine never stops reminding us) and sometimes errors and problems do lie in systemic, functional issues that ought to be fixed – like that ICU checklist everyone’s so keen on or better labeling on medications and so on. But an over-focus on process and a lack of understanding of the underlying messy complexities of medicine not only aren’t the answer but are increasingly becoming part of the problem.

Talk to any person who’s recently experienced hospital care and what you hear is just how vigilant you have to be and just how essential it is to have someone there with the patient to ensure the clinician walking into the room actually knows who the patient is and what his or her problem might be, what drugs s/he might be on, etc.

Comparing medicine to aviation or to BMW’s is ridiculously reductionist and ultimately counterproductive since one of the basic aspects of physiology is that it is not simply what is done to the patient but what the patient does back so to speak. With drugs, it is not merely the effects that the drug has on the body (pharmacodynamics) but what the body does to the medication (pharmacokinetics). The arrows, should one care to diagram it, go back and forth and every which way.

Treating people like units of production was exactly how this mess all started. And Ikea simply doesn’t have an organizer for that.

Voodoo Medical Science

Where to begin, where to begin.  I get busy with end-of-semester things and head out of town for a few weeks and poof! Bloody chaos.

Women’s reproductive rights suddenly back on the table in the U.S. and the legality of abortion tabled in the House of Commons here as a private bill.  Good grief. Was that plane I took the one in that Twilight Zone episode; the one that goes through the clouds and goes back in time?  More idiocy in the Commons, with this ludicrous Omnibus bill as they’re calling it.  Long guns taken out of the registry which means that automatic weapons can more readily be sold in Canada.  And of course zombie killers. (OK, that last one was ghoulishly interesting, I have to confess.)

And in health care news, as always some bright lights insisting they know what’s best – most recently a report from researchers at McGill (the term researchers usually being code for statisticians) expressing shock, shock I tell you, that drugs are used off-label when this lacks “scientific support”.

Um, OK. So what scientific support would that be? Drug company funded clinical trials – given that all other funding has been cut to the bone? Or do they actually mean data which, I would remind you, does not equal knowledge and can be massaged, manipulated and moulded to fit the theory-du-jour.

One class of drugs these experts took exception to was the use of anti-psychotics in situations where no clinical trials had been done. Years ago a physician friend of mine discovered that one of the anti-psychotics, quitiepine I think, seemed to help a patient with Huntington’s with some of her more onerous symptoms. But of course Pharmacare wouldn’t pay for it because – yup, you guessed it – there was no “evidence” that it worked for Huntington’s.  And naturally we all know that everyone, especially drug companies, are lining up to do an expensive drug trial with a teensy subgroup of patients with a rare, fatal, genetic disease ….

Needless to say, there’s never going to be “scientific support” for this. A point these McGill researchers who’ve clearly never had to deal with an actual patient don’t appear to have twigged to.

Research, clinical trials are expensive, time consuming and difficult to do. Who in their right mind is going to fund one for an old drug that’s no longer on patent that’s been around forever – but that still helps a lot of people? Not going to happen.

The pendulum has so swung so far, moreover, in favour of the stats and the algorithms and the “evidence” that everybody from Obama to your pharmacist to that nice young doctor in the clinic down the road honestly believe that medicine is a science and if we could just figure out the right questions to ask and do the right research (which  angels – taking time out from their dancing-on-a-pin thing – would fund) then All Would Be Revealed and we would all live happily and healthily ever after. As if.

What few people realize, alas, is that the bedrock of “scientific” medicine, the clinical trial, is very recent –though to hear people ramble on about  it you’d swear the dratted thing was on one of those tablets Moses brought down with him.

1948. That’s when the first official clinical trial was conducted: by the first medical statistician on record, Bradford Hill, who gave one group of patients with TB streptomycin (then a very new drug) and another group nothing. The idea took off and before his death in the 1990’s Hill’s book on medical stats (Principles of Medical Statistics) was in its 12th printing.

Hill was no dummy though and realized he’d created a monster. He backtracked. Where once he’d exhorted statisticians to “rise from their humble place” to help medicine become more scientific through the clever application of numbers he suggested we should “relax and reflect”; that such single-mindedness could easily lead to poor patient care: “cookbook medicine”.  It would be better, Hill wrote, if clinical trials were designed to “promote rather than hinder the traditional method in medicine of acute observation … by the clinician at the bedside”.  (All quotes from Richard Horton, the editor of The Lancet writing in 2000 in the journal Statistics in Medicine, “Common Sense and Figures: the rhetoric of validity in medicine” Vol. 19, pp 3149-64)

Probably what Hill had not appreciated in the early fifties as he began his little crusade was the extent to which post-war enthusiasms, technological advances and various social, political and institutional changes – ranging from the ascendancy of the United States to the shifts in finance, corporate influence and law – would transform his notions into a paint-by-numbers fiasco.  Biomarkers and surrogate end points (blood sugar, cholesterol, blood pressure, bone density) would reign supreme and you could feel perfectly fine but be told you had minutes to live.

Then it was EBM guru, David Sackett who picked up where Hill left off. Ably assisted by the new profession of health economics whose sole purpose it was to assist payers (like HMO’s in the U.S. and governments of countries with public health care) cut costs (and realized this statistical scientific rhetoric could aid their cause), the newly minted evidence-based medicine or EBM took off like wildfire, leading to the proliferation of guidelines and Hill’s cookbook medicine.

Sackett also backtracked, emphasizing that “the practice of evidence based medicine means integrating individual clinical expertise with the best available clinical evidence” everybody pretty much ignored him. After all, who cared if patients were different and physiology, difficult; as long as you had your bullet form guidelines and decision trees.

Meanwhile, everybody forgets that evidence has serious limitations, not the least of which is human error, external validity (in other words the people in the trial are not representative of the people in the community who actually take the drug or use the treatment) and conflicts of interest. At best even the best designed of trials tend to encapsulate a narrow slice of life which is not the reality of medical care which tends to be centred around the elderly and those with chronic conditions. (duh)

The old and the sick, precisely the people who use medicine, are excluded from clinical trials; in fact as Bradford Hill pointed out, the clinical trial “at best shows what can be accomplished with a medicine under careful observation and certain restricted conditions”.  I won’t even mention the exclusion of women from trials until the NIH stepped in in the ‘90’s to enforce its own regulations because the top of my head would blow off and that would create such a mess.

Ironically, where scientific medicine and epidemiology do excel is at giving us clues as to what doesn’t work, e.g., in common preventive measures such as mammography and PSA testing. But we don’t like those recommendations so we ignore them.

Turns out the “science” of medicine is like the Sasquatch. Often sighted and excitedly talked about but not actually real.

Oxy-Addiction-Nonsense Goes on

When I began writing these musings on the general idiocies going on all about us I wrote something to the effect of, “well, somebody has to say something”. (see post). Too true. So. In recent weeks you may have noticed some rumblings about Oxycontin, an opioid painkiller being discontinued; the replacement drug is similar but apparently less easy to abuse (OxyNeo).

The drug manufacturer has kept the price the same. Government health plans do not appear to have been as circumspect; my understanding is that there are plans afoot to delist the new drug and make it harder for people with chronic pain to have their pain meds covered. Terrific.

Just as noxious is the addiction narrative that has taken over  all discussion around this subject – with all its moralistic, judgemental overtones.  I keep waiting for a nice Puritan gentleman in a stove top hat to mince up and stick a big red A on someone.

A promo for the CBC’s Fifth Estate proclaims that addiction to Oxycontin costs us all, as taxpayers, untold amounts and they’re shocked, shocked, that this has been going on for so long.

Um, exactly what nefarious something has been going on? People in pain had some access to a medication that could provide a bit of relief? People in hospital who’d had surgeries and procedures were able to survive without being in agony? How did pain become a crime – and that tiny fraction of people who take a drug for purposes other than what it was intended for turn into such objects of scorn?

So yet again, another abbreviated history lesson. About 50 years ago we began to realize that how medicine treated pain was stuck in the Dark Ages. How that happened was some physicians who realized their post-surgical pain relief was a giant joke. (And being doctors didn’t give them any special status – which must have come as a real shock). They realized what patients went through, being accused of faking or exaggerating or being drug seeking addicts when all they had was pain.

Medicine’s treatment of pain was a “cool and callous disgrace” according to one doctor writing at the time.

With time things gradually changed, a bit. There was research and Melzack and Wall’s seminal book on pain and major scientific effort (see the International Association for the Study of Pain, IASP, site for more.) We began to understand that if  acute pain was well controlled the odds of it becoming chronic went down. That sometimes chronic pain happened – sometimes for no reason (hence the term ‘idiopathic’ which essentially means who-the-hell-knows) and sometimes because of underlying conditions like rheumatoid arthritis or scar tissue from a former injury. (Occasionally even as a result of iatrogenesis – caused by medical intervention, in other words. Some test or procedure gone wrong.)

Heck, we didn’t even realize until maybe 45 years ago that children felt pain. Infants.  Which explains those bone chilling videos from some years ago where baby boys’ screams as they were being circumcised were simply attributed to, I don’t know. Joie de vivre?

We didn’t even concede that post surgical and post traumatic pain was worse at the start (right after the surgery) and better a few days later. Hence PCA – patient controlled analgesia – where individuals can give themselves a programmed amount of medication when they feel pain rather than waiting for the requisite number of hours to have passed before the nurse could give them a dose.

We even realized that we could give the dying a modicum of dignity and autonomy by controlling their pain. Because really, who on earth would care if a dying person got ‘addicted’ to morphine? Which they don’t but that’s another story.

Most important we began to realize that there’s nothing ennobling about pain. Pain just hurts.

Not that you’d realize it these past weeks as the moralistic jingoistic nonsense carries on in the media with the Oxycontin issue. Nope, the real issue is addiction. Tsk tsk.

Lost in all this is any sophisticated thinking or mature discussion as we forget the complexities of pain; how physical pain is exacerbated by stress and fatigue and hunger and other conditions. So that phrase we bandy about: ‘most common in northern communities’ might actually have its basis in what actually goes on in those northern communities.

First Nations reserves without gobs of mineral reserves and cash where individuals live  socio-economic conditions most of the rest of Canada would find unacceptable. After all, if your community and your culture are not valued; if your hopes are few and your living environment horrid – perhaps addiction might be the natural result. So Sherlock, perhaps addiction is the symptom, not the underlying “disease” (if we wanted to reduce our argument to mere medical parametres).

For a lot of people opioids (oxycontin, morphine, methadone, codeine or the synthetic variants like demerol and fentanyl)  – especially in conjunction with other techniques like exercise, self hypnosis, pacing oneself and other such things – allow people with chronic pain to function. Unfortunately, pain clinics that give people that broader perspective and help them learn not to rely solely on drugs have slowly been disbanded over the years (we prefer spending money on high tech toys) so now more people rely solely on medication to help them cope with pain.

I had thought, erroneously as it turns out, that we had matured somewhat when it came to our attitudes towards pain; that we understood that pain is the one condition that unites us all – wherever we live, whoever we are. But I suppose all that thinking was giving us a headache, and without any Oxycontin on hand ….

 

(to be continued)

And the mammogram nonsense goes on …

Given my previous curmudgeonly rants about the general uselessness of mammograms I was pleased, nay, delighted when when the Canadian Task Force on Preventive Health Care issued new guidelines – ever-so-gently suggesting that perhaps this pop culture myth that ‘mammograms save lives”, especially that of younger women, is a crock. Naturally they phrased it in dry, epidemiologic language, but you’d thought the poor geezers had suggested women shouldn’t be allowed to vote.

The response, anecdotal, I’ll grant you but shrill, emotive and generally overwhelming was: Well! How dare you condemn women to death you dreadful guideline-writing scum you. Letters poured into newspapers and editorials pilloried the Task Force – the inevitable line was “having a mammogram saved my life”.

Politically incorrect and uwomanly of me it may be, but my first thought was, ‘Really?! How do you know? Given that a teensy mass that couldn’t even fill the head of a pin is now called a cancer and the person who’s had it a survivor?’

Perhaps less vocal people felt relieved that the Task Force had articulated what they had thought all along, that it may not be such a splendid thing to squish your breasts between two metal plates once a year even as you ended up dosed with radiation but I don’t know.

As far as I’m concerned the Task Force didn’t go far enough. They clearly stated that women who had the BRCA1 and 2 genes or had a family history continue to have regular mammograms, even as early as 40 and added that older women, those over 70, should also be screened. They politely did not say, trust us, if you have cancer you’ll know it. Ideally, a mammogram will find a fast-growing cancer early. By and large, it won’t. What it will find is what all those cancers that don’t want to be found, the bits and pieces of slightly abnormal tissue we all have – and which will be found if we go looking for trouble. Which is essentially what screening is.

Alas, screening is all too often confused with ‘cure’. Or ‘treatment’. Which screening simply cannot be. Screening is a way to make obvious something that was there that we didn’t know about, theoretically to ‘catch’ something dangerous early. As if.

But, hey, we’ve got the runs for the cure and all those pretty celebrities (and nonentities) going on the telly to lecture us on how we should all be focused on preventive care and take our radiation. Or have someone thrust a sharp object up our colon. Yes, sharp. The kind of thing that can slip and perforate the bowel and have you in the ICU faster than you can say colonoscopy.

But I wax incoherent.

So, once again, a brief lesson in how cancerous cells evolve. Cells divide over the course of their and our lives; with each division the odds of a ‘mistake’ increases. Which is why cancer is generally a disease of old age. The more those cells divide the greater the odds that something will go askew and result in what, if found, we will call cancer or pre-cancer or some damn fool thing. (Of course as we get older our cells divide more slowly which is why most older people die with cancer not of it.)

Then we attack what we’ve found with all the tools of the early 20th century: radiation, surgery and harsh drugs. True, a handful of cancers are actually treatable with some new meds, usually fairly rare cancers, and a few drugs can increase life span. We are better at targeting and focusing and not killing quite so many non-cancerous cells. But the reality remains that we’re still focused on zapping and poisoning and cutting out cancers, just as they were in close to a hundred years ago and, barring the smoking/lung cancer connection, no closer to understanding why some people get cancer and others don’t.

That’s the question we should be asking and flinging money at, not mammograms.

Of course why the guidelines come as a shock to anybody I do not know, since we’ve known, definitively, since the 90’s that mammography is a crude screening tool at best. Plus, for women under 50 the risk benefit ratio is beyond ridiculous. (What we really mean by that, of course, is women who have not yet gone through menopause not women under 50 but we do love our decimal groupings – maybe it’s that counting-on-ten-fingers thing, so much easier). In other words, the number of false positives, biopsies to confirm one does not have cancer and actual false diagnoses are phenomenally high. (That last one, by the bye, simply refers to the women who end up being told they have cancer when they do not and end up in that most dismal of all “treatment” regimens for no reason at all.)

We have also known for a long time that not all cancers want to be found; that in fact over-diagnosing and over-treatment are rife when public policy institutionalizes screening, whether it’s PSA testing or colonscopies or mammograms.

But the emotional anecdotes continue to mount as individuals tearfully ask why the rest of us (and that nasty Task Force) would condemn them to death. Ah, easy there sport. Nobody’s condemning you to anything. Yes, women do get breast cancer. We have all had a friend or relative die of the disease. (Yes, including me. I sat with her as she died.) But simply because something happens does not mean it’s an epidemic or a scourge.

Finally, health policy is not clinical practice. Policy, guidelines, are simply a way for institutions to recommend what appears to be best practice. This does not mean that individual women cannot have mammograms or that individual doctors cannot counsel individual patients to have them. It simply means that a blanket policy recommending all women over a certain age undergo a procedure that is neither benign nor risk free is not a good idea.

Furthermore, something the Task Force did not mention, probably because they did not know it, is that women prior to menopause go through a phrase of life called perimenopause. Perhaps you’ve heard of it. It’s the years leading up to the cessation of the menstrual cycle when some women have hot flushes and mood swings and can get depressed and irritable. Estrogen levels fluctuate during this time and estrogen, boys and girls, is a hormone that causes cells to proliferate. It does that in the uterus during the menstrual cycle and also in the breast. So, the risk of a false positive raises commensurately for perimenopausal women because higher estrogen = lumpy breasts. More often than not these will resolve, go away, with time as an elegant Scandinavian study demonstrated some years ago.

So tell me again why women in their 40’s would want to subject themselves to this? Oh yes, because they believe in the medical model and the linear nature of physiology. Worst, we have all been subjected to such a barrage of pink ribbons and nonsense about prevention that women honestly believe the dratted technology actually works.

For my part, a certain weariness sets in as I watched this play out, not to mention the inevitable expert huffily saying, look, it’s science and you can’t argue with that. Actually I can. But this is one time the best-guess statistics, hypothesis testing, and empirical data all back up the physiology and common sense.

But I guess a lot of women have decided that the Forces of Evil want to take their mammograms away. How does one explain the Forces of Evil have a lot more on their mind these days than women’s breasts?

Mental Health Misunderstood. Again.

According to yesterday’s Globe and Mail, a report from the Vancouver Police Department identifies the deinstitutionalization of the mentally ill as a major problem for police, who have become de facto mental health workers.

“We certainly have identified individuals that we wonder whether it would be healthier – both for themselves and the community – if they were in institutional care,” Vancouver Police Department Inspector Scott Thompson is quoted as saying at a press conference. “The difficulty,” he added, “is that [that] is a medical question. That’s not within the realm of policing.”

Ah, but there’s the rub. It’s not a medical question or medical issue or even a medical decision. It’s a political and economic and sociocultural one.

When the decision was made to – for all intents and purposes – shut down the single major institution this province had for the mentally ill, Riverview, it had nothing to do with the doctors and nurses and social workers; it was a decision made at the Ministry of Health and provincial and federal level. It had to do with the general tenor of the times, notions of autonomy and individual rights  – not to mention a way to save cold, hard cash.

Riverview, once upon a time

To some extent it was in reaction to the authoritarian, pseudo eugenics-type of position taken in earlier decades where the mentally ill were forcibly sterilized, forced to undergo horrible procedures (like frontal lobotomies – driven by the enthusiasm of a single nutty doctor incidentally) and unethical experiments on prisoners and others considered somehow lesser human than the rest of us.

Now the chickens have come home to roost. The downtown east side is a morass of misery and it is the police and the justice system who increasingly have to deal with people who are incapable of making rational choices for themselves. People who live next door to drug addicts and pushers and pimps.

Yes, it is a disgrace and yes, many of the people are sick and would do far better in the wooded confines of Riverview Hospital. But we’re closing Riverview (the scuttlebutt is that the land is worth a mint and that plays a major role as well)

Many years ago I wrote a document for and on Riverview; I spent a few days wandering the grounds and halls, talking to psych nurses and doctors and patients and all kinds of people. I watched as mentally ill individuals happily wandered through the garden and attended art therapy and crafts workshops. If they had a bad episode there were medical professionals on hand to help.

But.

As a society we decided a long time ago that we couldn’t afford it, that it wasn’t a viable alternative, that it wasn’t the way to do things.

Now the police are unhappy about how it’s all unfolded and most of us don’t like it much either. But it’s not a medical decision. Or even a personal one – talk to the families of schizophrenics or people who feel fine on meds and decide they don’t need them any more, become psychotic and head for the hills. Even if the hills are only in their mind.

Mental illness is complex and misunderstood – but it’s not medicine that’s let us down. It’s ourselves.

The clinical arts made clear

For years I have been whinging on about the overuse of medical technologies, in my writing, teaching, speaking (occasionally stooping so low as to corner a hapless victim at some dull cocktail party who’s made the mistake of innocently asking me what I do/am working on). And finally, the Archives of Internal Medicine has backed me up with a new, elegantly designed study from a group of physicians in Israel.

(Oh North America, why do you ignore the nuanced questions? Why is it that American and Canadian researchers confine themselves to reductionist questions like Pax2-dependent transcription activation and other such unpronounceable minutae, leaving the critique and analysis to the Israelis and Finns and Norwegians and Dutch and so on?)

Then again, it is not just researchers but us on this large continent, we who believe in high tech and guidelines, rules and benchmarks. We has seen the enemy and he is us, to coin a phrase. Our cultural template, our social world, our beliefs and values predispose us to believing in the power or science and technology; we love our smartphones so medical technologies – those lovely acronyms like MRI, CT and PET – must also be the royal road to answers. So we push push the doctor to send us for “tests” so we too can receive our god-given right to radiation.

What we inevitably forget (or just don’t know) is that what medical technologies measure are, at best, only pale imitations at best of the complexities of disease and illness.

When I remind students – seniors, undergraduates, their ages don’t matter – that “an MRI or CT scan can’t tell if that lump is benign; it’s a person, a human being who makes that determination” I can see that shock in their faces.  Because the seem to have forgotten that it is a fallible human being, prone to errors and fatigue and over- and lack of confidence who figures out the test, not the computer/technology.  And people can miss things, over- or under-report; people can exaggerate a problem because they’ve been sued or are in a hurry to get home and get to their child’s soccer game.  (Came as a shock to you too, didn’t it? You kind of thought technology trumped clinical judgement as well.)

Back to the Israeli study done by Liza Paley, MD along with physician colleagues Zornitzki, Cohen, Fredman, Kozak, and Schattner. They examined newly admitted patients to the emerg for 53 days, checking to see if the various tests and scans and so on ultimately aided in the final diagnosis. Sure enough, and wonderfully confirming my own cranky comments, they found that “more than 80% of newly admitted internal medicine patients could be correctly diagnosed on admission and that basic clinical skills remain a powerful tool”. In other words, with only a handful of old, cheap lab tests (which were found to be “crucial”) plus a detailed history and decent clinical skills, you could narrow down the diagnosis and figure out how to treat the patient.

In fact, up to 90 percent of correct diagnoses were the result of history, exam plus some basic blood work (hematology and chemistry, urinalysis, EEG chest x-ray – which, I would remind you, contains anywhere from a tenth to 1/400th of the radiation of a CT scan.

These are not the tests we associate with medical high tech though. These are old tech, based on boring old 20th century research. No genetic tests, no cool monitors or flashy gadgets.

“Our results do not mean that sophisticated studies need not be used after admission, but they do suggest that their choice should be guided by the clinical data on presentation,” wrote the authors  in the Archives.

Of course our complicity in all this, particularly in community medicine, was a not a part of this study; neither was our belief, our faith in the power of the technology; superhuman, infinitely superior to the biological brain and, of course, infallible. Stemming from our belief that disease somehow has an independent reality – that it is the “other”, evinced by our metaphors (“killing” the cancer, “fighting the disease) and attitudes – that is observable through “scientific” means, ergo technology.

In fact disease and illness are nothing of the sort. A manifestation of human frailty, highly individual and affected by everything about us and around us: who we are, who we were, our personal and family history; our lives and fears; our environment and social biases – all the many stresses and strains we’ve been exposed to, from what we ingested to what we’ve invested. Ultimately, what matters isn’t that label, that diagnosis, however much it might provide us with comfort, but the care we receive.

And that, boys and girls, is the art of medicine without which the science hasn’t got a chance.

Physiology 2.0

An older woman of my acquaintance misplaced her watch recently. Not a big deal, you’d think. She found it a few days later with the help of a friend – unbeknownst to her it had slipped off the television and into a drawer. What got my attention was her extreme secretiveness, so convinced was she that people would suspect she had Alzheimer’s or dementia or what-have-you (because of her age).

Somewhat in the same vein I am often asked – in strictest, pain-of-death confidence – about a pain here, a twinge there; a slow-to-heal cut or some bleeding that my interlocutor is convinced is something dire, cancer probably. Almost always with some judicious questions I can reassure the person; the pain is probably a pulled muscle (if it doesn’t improve over time then perhaps further investigation might be called for), the blood loss benign (and common), the cut merely infected and in need of antibacterial care. The relief is inevitably palpable. Terror had literally been keeping the person up nights.

I don’t blame them. Everything they hear about health, and there is a lot of it around, is about something horrible. In truth, we are all so inundated health “news” these days, so saturated with medical “updates” – in every medium possible – that it’s virtually impossible not to become a hypochondriac at one point or another. Especially since medical problems are presented not in terms of real physiology which is messy, unpredictable and slow (but often very resilient) but in entertainment terms: Monster tries to eat New York, hero rises to vanquish monster, stuff happens, the end.

The heroic angle is ever present. We will discover the gene that “causes” cancer (Really? How’s that working out?), tweak it and presto! Problem solved. Well, not right this instant of course. Oh, and did we mention there are these fibres in those bags you now use to carry groceries that can cause beri beri? Oopsy woopsy.

That’s not how physiology works.

From the immune system to neurons, our physical selves advance, retreat, retrench; go forward one step and back two (even with something ostensibly simple like a flu virus). Age on the one hand creates fragilities, on the other speaks to great endurance (hey, there are a lot of chances to die before you hit 75). Physiology is complex, dynamic and infinitely changeable, even in the same person, from one moment to the next.

The root of this reductionist thinking came after the second world war when money and attention, not to mention serious institutional support, went towards medical research, the National Institutes of Health, Health Canada and the like. And our focus, as the late Yale epidemiologist and physician Alvan Feinstein wrote, turned away from the person (patient) and towards disease. Plus, we started flinging large sums of money at medical research which, in turn, began singing its own praises, which is hard to do unless you create a bogeyman you are battling.

So, nobody mentions that we live longer, healthier lives (in the developed world) than any generation ever. That over half of all people over 65 are alive today and doing very well thank you very much. What we do hear is that there are umpteen dreadful diseases out there, skulking, lurking.

So we freak out over minor aches and pains and mumble “Oscar material” when some fellow played by James Franco heads into some canyon and gets stuck. Look, I’m glad the fellow saved himself and yes it must have been dreadful but the real story is not dramatic but in the day-to-day lives of all those amputees who have to cope with getting on with their lives. The real story isn’t in the escape but life after that idiotic daredevil stunt. Except life with a disability is painfully difficult, often humiliating and can make even a grown man cry from frustration. Boring. Not at all Oscar material.

Is it any wonder real life, only too often – when it hits, as it always does – comes not only as a rude shock but as a personal affront?

Take another curmudgeonly peeve of mine. Violence. Movies, television shows, games – the level of gore has steadily increased even as our ability to emphasize or react in any appropriate form has gone down. Sure, I enjoy watching the evil genius get his or (more rarely) her comeuppance; I like a watching a building blow up and cops shooting at bad guys. What I do not enjoy is the inevitable desensitization these increasing levels of violence have on our collective psyches. (Or the noise: I seem to be the only person in the western world with intact hearing.)

It seems that we have all become so immune to the ugly impact violence has that even an essentially comic-book hero like James Bond is portrayed not as the suave Sean Connery straightening his cuff links after a dustup but is rife with fake blood and cringe-worthy torture scenes that make one feel vaguely ill.

Then. Then. (Here we have to pause for me to give a heavy sigh.) Then, the victim of aforesaid torture or flying bullet gets up and carries on. If he’s the hero, that is. Later, we hear that he was lucky, the bullet “grazed” the skin, it was just a flesh wound.

Pardon me?! What flesh would this be? Um, human? Frankly, I have yet to meet a real human being who was able to recover from even a kitchen accident in a day. (Hey, you try it. Make a deep slice in your finger as you’re chopping carrots or a slice of bread and you tell me how long it takes to heal. More often than not you’ll take the bandage off way too soon, the cut gets infected and starts to throb and the whole process starts all over again.[1]) The consequences of violence are so rarely seen as to be invisible.

No doubt this is why we get those news items of seven-year-olds firing on one of their pals in jest without realizing that real guns do real damage.

Physiology is hard. Healing takes time. Bodies are fragile yet amazingly resilient. It all depends on the person, the situation, the amount and place of the damage. Even a broken ankle can lead to a lifetime of causalgia (you don’t want to know – major, lifelong pain) and someone can fall off a cliff and survive with minimal injuries. It’s not possible to predict and it’s probably better not to try that last one. Politically, such attitudes end up reflected in the acceptance for President Bush’s redefining torture in defiance of the Geneva Conventions and in our nonchalance around so much global suffering – even as it convinces us that we’re dying from some dreadful disease – when all we’ve got is a hemorrhoid.


[1] (First Aid note: when you’ve cut your finger or hand and the skin has healed over but it’s red, swollen and painful, what’s happened is that bacteria are trapped and your immune system is responding, but slowly. To help the macrophages along, you need to clean out the bacteria physically by making a tiny incision and letting the blood and pus ooze out. Sounds horrible but there’s physiology for you. Then soak in hot water with a drop of disinfectant, e.g. Dettol, or just water in a pinch.  Cover with antibacterial cream and bandaid.)

Staying Alive

The absurdity is beyond irony. In a country obsessed with “proactive” health, screenings and tests; a country where celebrity figures urge everyone to “fight” this or that cancer with mammograms or colonoscopies or PSA tests; a country that spends over 16% of GDP on health care and still has the poorest health outcomes of any developed country, one of the biggest threats to health is an amendment to a 300-year-old document professing the right to “bear arms”.

Originating in a different time and frame of mind, the American constitution was a masterpiece of hope and imagination; that “well armed militia” (bearing aforesaid arms) and hope, all that stood between a young country and its colonial past.

Today, in the age of iPads and wifi, environmental change and globalization, it all seems so sad and silly. Particularly in the wake of the tragedy in Tucson a few weeks ago, where a Congresswoman and many others were wounded and six people died.

In terms of health it seems to me that that the United States would do well to stop its preoccupation with political rhetoric (not to mention those colonoscopies) and – for five minutes – consider whether the number of guns in circulation might, just might, have something to do with the incident.

bang bang, you’re dead (the healthiest corpse I’ve ever seen)

As the Economist put it:  (January 15, 2011 print edition, here)

“Opportunists who seek to gain political advantage by blaming the shootings on words would do America better service if they focused on bullets. In no other country could any civilian, let alone a deranged one, legally get his hands on a Glock semi automatic. Even in America, the extended 31-shot magazine that Mr. Loughner used was banned until 2004. As the Brady Centre, established after the Reagan shooting to commemorate one of its victims, has noted, more Americans were killed by guns in the 18 years between 1979 and 1997 than died in all of America’s foreign wars since its independence from. Around 30,000 people a year are killed by one of the almost 300m guns in America – almost one for every citizen. Those deaths are not just murders and suicides: some are accidents, often involving children. The tragedy is that gun control is moving in the wrong direction….”

I couldn’t have said it better myself.

“Information is power” (not)

As I raced through Waterfront Station last week, late for something or t’other, I overheard a well-dressed young man intone, “Information is power.” The pretty young woman he was with enthusiastically agreed.I moved on, dodging slower pedestrians and trying to figure out why and how such a cockamamie truism had taken such a stranglehold on us all. Information is power? Says who?

Information, aka data, is not even knowledge, never mind power. Without context, without a hypothesis, without a narrative of some kind, simply having access to Google and disparate bits of information means nil.

Anyway, isn’t the usual phrase knowledge is power? And even knowledge, moreover, rarely translates into power- unless you’re a blackmailer.

Unfortunately, the cliché has taken off and far too many people actually believe that having access to information, be it minute by minute stock/business data, medical information or Google (“facts”) actually means something.

Let’s take one example of basic information: observational studies. We observe one thing, see that it seems to happen whenever something else does and presto, we have a correlation on our hands that we conveniently forget are simply disembodied bits of information that probably mean nothing – but which we assume reflect cause.

Epidemiology had one major success with that: cigarette smoking and lung cancer. And they’ve never let us forget it. The problem is that almost no observational studies epidemiology threw at us ever turned out to be accurate when properly scrutinized.

Take the estrogen debacle. For years observational studies and epidemiology insisted that women who took estrogen, particularly at midlife, were healthier, lived longer, had fewer heart attacks and even suffered less from dementia. The problem was that this link came from well-off women who had the time to fill out those surveys and questionnaires, which meant they were better educated and of a higher socio-economic background. This meant that they were also healthier – in fact there’s even a name for it: the healthy user bias. People who are from a higher socio-economic status are healthier. Period. Why? We don’t know.

Perhaps they eat better or have less stress; perhaps they have better genes and it’s that which has led them to be better off in the first place. Maybe they breathe cleaner air and live in nicer areas where they don’t breathe or step in toxic gunk. After all, it’s not the CEO of a company, whether in India or the United States, whose house abuts the factory runoff, it’s the hapless janitor and his family who can’t afford anything better.

The media loves reporting on observational studies, where the inevitable term used in the headline is “linked”. Vitamin D is “linked” to better health. In healthy societies women’s choice of mate is “linked” to more masculine features, which naturally means that evolution has had something to do with the preponderance of older men marrying women young enough to be their daughters.

We forget that correlation has nothing do with cause. The Women’s Health Initiative clinical trial was stopped early because it was the women who took estrogen who were dying in droves from breast cancer and heart disease. All those years researcher upon researcher had insisted that their hypothesis, namely that estrogen was the female hormone, was right and had absolutely nothing to do with the binary nature of our socio-cultural classifications. But gosh, they were wrong.

Failure of imagination follows in the tracks of information – simply knowing that something happens tells us absolutely nothing about why it happens or whether manipulating one factor will have an effect on the other. It could be incidental, an artifact, or just plain wrong.

Still, we walk around, secure in the knowledge that our platitudes, like information, give us an edge.  But it’s not power, just swagger.